Figure 9.

Rapamycin (RAPA) abolished the protective effect of modafinil on spatial memory of sleep deprivation (SD) mice. (a) Representative swimming tracks of sleep—deprived mice in Morris water maze test. (b) Frequency of crossing the platform of mice after sleep deprivation for 24 hr. (c) Frequency of crossing the platform of mice after sleep deprivation for 48 hr. All data presented are means ± SEM; N = 10 per group. *P < 0.05, significantly different from control; ^# P < 0.05, significantly different from control + rapamycin group