Figure 2.

High doses of WIN55,212‐2 decrease spontaneous locomotion. (a, b) The time course and AUC measurements after systemic administration of different doses of Δ⁹‐THC or vehicle in the open‐field test revealed a significant time main effect (two‐way ANOVA for repeated measures, F_{11, 77} = 5.93), but no significant Δ⁹‐THC treatment main effect (F _{3, 21} = 2.30) or Treatment × Time interaction (F _{33, 231} = 0.39). (c, d) In contrast, WIN55,212‐2 administration produced a more pronounced impairment of spontaneous movement in the open‐field test (two‐way ANOVA for repeated measures revealed a significant Time main effect (F _11,77 = 6.35), treatment main effect (F _3,21 = 7.08), and Treatment X Time interaction (F _33,231 = 1.97)), shown here by the time course for individual doses (c) and the AUC summary data (d)