Figure 6.
Effects of ACEA and JWH 133 on open‐field locomotion. (a) Time courses of basal levels of locomotor activity after systemic administration of different doses of ACEA or vehicle, illustrating that ACEA did not significantly alter open‐field locomotor activity. A two‐way ANOVA for repeated measures over time and drug dose revealed a significant time main effect (F 11, 77 = 5.93, P < 0.001) but no significant ACEA treatment main effect (F 3, 21 = 2.230) or Treatment × Time interaction (F 33, 231 = 0.38). (b) The AUC data from (a) after ACEA administration. A one‐way ANOVA for repeated measures over Δ9‐THC dose failed to show a significant treatment main effect (F 3, 21 = 2.30). (c) Time course of the effects of JWH 133 on open‐field locomotion. A two‐way ANOVA for repeated measures over time and drug dose revealed a significant treatment main effect (F 2,14 = 6.74), time main effect (F 11, 77 = 1.68), and Treatment × Time interaction (F 22,154 = 2.86). (d) AUC data from (c) after JWH 133 administration. A one‐way ANOVA for repeated measures over dose revealed a significant JWH 133 treatment main effect (F 2,14 = 6.74). *P < 0.05, significantly different from vehicle group