Figure 2.

WHISTLE website. The WHISTLE website hosts a functionally annotated high-accuracy predicted map of the human m⁶A epitranscriptome. The WHISTLE website supports direct query of RNA-methylation sites with respect to a specific GO function or gene. The m⁶A RNA-methylation sites were predicted from m6A-CLIP data, miCLIP data, sequence features and genome-derived features. And then, the most dynamic RNA-methylation sites were annotated under the Gene Ontology framework using the guilt-by-association principle by integrating gene expression, RNA methylation and protein–protein interaction data. Please Supplementary Figure S2 for the complete data processing pipeline of WHISTLE.