Table 4.

Performance assessment using high resolution m⁶A-seq data

	AUC under full transcript model	AUC under mature mRNA model
WHISTLE	0.980	0.904
MethyRNA	0.904	0.826
SRAMP	0.825	0.783
RMBase	0.774	0.758
MeTDB	0.775	0.767

Note: The high confidence consensus m6A sites detected in more than two of the total six high resolution m6A-seq experiments (57) were considered. Similar as before, MethyRNA and WHISTLE used the same m6A datasets for training. Only the unique sites not previously reported in the training data were considered here. Please see Supplementary Table S5 for the results when all sites from the independent testing samples were considered.