Table 3.
Sensitivity analyses in rule-out using biomarkers and ECG.
| NPV | Sensitivity | PPV | Specificity | |
|---|---|---|---|---|
| hs-TnI 0 h ≤ 3 ng/L AND low risk ECG | 100 (98.5, 100) |
100 (98.5, 100) |
25.4 (22.7, 28.3) |
25.9 (23.1, 28.8) |
| hs-TnI 0 h ≤ 3 ng/L AND low risk ECG AND suPAR 0 h < 3.7 ng/mL | 100(98.1, 100) | 100 (98.5, 100) |
24.1 (21.5, 26.8) |
20.4 (17.8, 23) |
| hs-TnI 0 h ≤ 6 ng/L AND hs-TnI 1 h ≤ 6 ng/L | 99.1 (97.8, 99.8) |
98.4 (95.9, 99.6) |
32.5 (29.1, 36.0) |
47.4 (44.2, 50.7) |
| hs-TnI 0 h ≤ 6 ng/L AND hs-TnI 1 h ≤ 6 ng/L AND suPAR 0 h < 3.7 ng/mL | 99.4 (97.8, 99.9) |
99.2 (97.1, 99.9) |
27.9 (25.0, 31.1) |
34.2 (31.2, 37.4) |
| suPAR 0 h < 3.7 ng/mL | 83.1 (80.1, 85.8) |
52.7 (46.2, 59.0) |
24.2 (20.6, 28.1) |
58.6 (55.4, 61.7) |