Figure 2.

FOXK2 transcription factor and chromatin-associated events. FOXK2 recruits AP-1 to the chromatin, regulating genes involved in cell-cell contact, motility, cell adhesion, metabolism, apoptosis and cancer. Besides that, FOXK2 interacts with BAP1, a component of PR-DUB complex, leading to local histone deubiquitination and to repression and/or activation of transcription of target genes. In addition to these chromatin-associated events, FOXK2 binds to methylated DNA as well as interacts with MBD6 and PR-DUB complex, recruiting transcriptional complexes. Furthermore, FOXK2 is potentially implicated in DNA repair functions, where it binds to G/T-mismatch regions and interacts with BAP1 deubiquitinase. BAP1, BRCA1-associated protein 1; AP-1, activator protein-1; PR-DUB, polycomb repressive deubiquitinase; MBD6, methyl binding domain protein 6; Me, DNA methylation sites.