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VRAC selectivity depends on the LRRC8 subunit composition. (a) VRAC made of the LRRC8A and LRRC8B/C/E subunits displays a large preference for Cl− ions over taurine, and no permeability towards cisplatin. (b) VRAC made of LRRC8A and LRRC8D subunits reverses the selectivity seen before, with large preference for taurine over Cl− ions. Most notably, this subunits combination, and this only one, makes VRAC very permeable to cisplatin.
