Table 2.
Clinical studies demonstrating the analgesic effect of radiation therapy on painful bone metastases depending on dose and fractionation regimen.
| Trial | Number of Patients | Fractionation | Complete or Partial Pain Response | Complete Pain Response |
|---|---|---|---|---|
| Price et al., 1986 [29] | 288 | 1 × 8 Gy 10 × 3 Gy |
73% 64% |
45% 28% |
| Cole et al., 1989 [30] | 29 | 1 × 8 Gy 6 × 4 Gy |
88% 85% |
NR 2 NR 2 |
| Gaze et al., 1997 [26] | 280 | 1 × 10 Gy 5 × 4.5 Gy |
84% 89% |
39% 48% |
| Nielsen et al., 1998 [25] | 241 | 1 × 8 Gy 5 × 4 Gy |
44% 46% |
15% 17% |
| Steenland et al., 1999 [24] | 1171 | 1 × 8 Gy 6 × 4 Gy |
72% 69% |
37% 33% |
| Koswig et al., 1999 [17] | 107 | 1 × 8 Gy 10 × 3 Gy |
79% 82% |
31% 33% |
| BPTWP 1 1999 [22] | 272 | 1 × 8 Gy 5 × 4 Gy |
72% 68% |
52% 51% |
| Roos 2005 [31] | 275 | 1 × 8 Gy 10 × 3 Gy |
61% 53% |
15% 18% |
| Hartsell et al., 2005 [32] | 998 | 1 × 8 Gy 10 × 3 Gy |
65% 66% |
15% 18% |
| Foro Arnalot et al., 2008 [23] | 160 | 1 × 8 Gy 10 × 3 Gy |
75% 86% |
15% 13% |
| Nongkynrih et al., 2018 [27] | 60 | 1 × 8 Gy 5 × 4 Gy 10 × 3 Gy |
80% 75% 85% |
20% 20% 20% |
1 BPTWP—Bone Pain Trial Working Party, 2 NR—not reported.