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. 2019 Mar 19;11(3):390. doi: 10.3390/cancers11030390

Table 3.

Pain response after re-irradiation of painful spine metastases [58,73,74,75,76,77].

Study Initial RT Dose (Median) Re-Irradiation Modality Re-Treatment Dose Pain Response
Choi et al., 2010 [73] 40 Gy (24.2–50.4) CyberKnife Median marginal dose 20 Gy/2fr (range 18/1–25/5)
30 Gy/5fr		 65% improvement in pain
Garg et al., 2011 [74] 30 Gy (30–45) IG-IMRT 27 Gy/3fr
20 Gy/5fr		 Improvement in pain at 6 months
Damast et al., 2011 [75] 30 Gy (8–66) IG-IMRT 20 Gy/5fr
30 Gy/5fr		 77% improvement in pain
Mahadevan et al., 2011 [76] 30 Gy (8–46) CyberKnife 25–30 Gy/5fr
24 Gy/3fr		 79% improvement in pain
Chang et al., 2012 [58] 39Gy Gy2 1 CyberKnife 20.6 Gy/1fr (18.2–23.7) 80.8% pain control rate at 1 year
Hashmi et al., 2016 [77] 30 Gy/10fr IG-IMRT 16.6 Gy/fr
24 Gy/3fr		 74.3% improvement in pain

1 Gy is a way to normalize radiation doses that may have been given in a different dose/fractionation schedule. It converts all doses to the equivalent dose in 2 Gy per fraction. Abbreviations: fr—fraction, RT—radiation therapy, IG-IMRT—image-guided intensity modulated radiation therapy.