Figure 5.

MP101 (DNP) tissue concentrations (ng/g) in mice. Six-month aged male C57/bl6 mice were fasted for 4-h and then provided MP101 at a dose of 0.5, 1, 5 and 10 mg/kg (Mitochon sponsored study conducted at Melior Discovery (Exton, PA, USA)). Four hours later, the cortex, liver and skeletal muscles were harvested to determine tissue penetration levels by LC/MS at Keystone Bioanalytical (North Wales, PA, USA). The brain levels were generally slightly lower than muscle, which was less than the liver (unpublished).