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. 2019 Mar 23;8(3):280. doi: 10.3390/cells8030280

Figure 8.

Figure 8

Paradigm shift from weight loss program to a wellness program. Extrapolating the human published data from the 1930s to doses that are significantly lower and likely within the hormetic range of inducing BDNF to gain synergy, while simultaneously partitioning lipids out of insulin-sensitive tissues at weight neutral doses. Human equivalent dose (HED) within this range offers the possibility to significantly improve whole body flux at safe doses using time as the primary variable.