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. 2019 Mar 6;11(3):312. doi: 10.3390/cancers11030312

Figure 2.

Figure 2

Targeting autophagy in GBM therapy. The effects of different therapeutic combinations on autophagy and the outcome on GBM progression in patients are shown. Chloroquine or hydroxy-chloroquine (CQ/HCQ) addition to standard protocols (TMZ/IR, temozolomide/radiation therapy) impairs the autophagy flux and sensitizes GBM to the treatment (pink box). Otherwise, several chemical compounds and mTOR inhibitors, that are able to stimulate autophagy, also increase the efficacy of the standard treatments (green boxes). THC, tetrahydrocannabinol.