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View full-text article in PMC

. 2019 Mar 22;11(3):402. doi: 10.3390/cancers11030402

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Detection of copy number variants in anaplastic thyroid cancer (ATC). (a) Breakpoint map of 10 primary ATC cases based on whole exome sequencing. Breakpoints were defined as a change in copy number state. A large number of breakpoints in centromeric regions were seen. (b) Heat map of copy number aberrations in 10 primary ATC cases. Polyploidy and large variations in chromosomal copy number were seen. (c) Expression of genes in amplified regions in all ATC cases and normal thyroid tissue.