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. 2019 Feb 26;11(3):276. doi: 10.3390/cancers11030276

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of napabucasin on functional cancer stem cell characteristics. (A,B): Results of soft agar colony formation assay of HuCCt-1 and NOZ cells. Data are presented as mean value ± SEM related to untreated control cells of four individual biological replicates. Cells were either pre-treated with napabucasin or treated with napabucasin for the entire duration of the assay (eight days). (C) Exemplary images of the soft agar colony formation assay (scale bar at the left bottom of each image represents 200 µm. (D) Effect of napabucasin on the ALDH-positive subpopulation of HuCCt-1 cells (n = 5 individual biological replicates). (E) Effect of napabucasin on the surface expression of the cancer stem cell marker CD326 (n = 6 individual biological replicates). * indicates significant (p < 0.05) results. Abbreviations: ALDH: aldehyde-dehydrogenase; n.d., not determinable; rfu, relative fluorescence units.