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. 2019 Mar 8;8(3):224. doi: 10.3390/cells8030224

Figure 1.

Figure 1

A schematic diagram depicting a role for Rab7a at the initial stage of mitophagy. Damaged mitochondria become coated with ubiquitin chains, proliferated on its outer membrane proteins by Parkin, which is recruited and activated by PINK1 stabilized on the mitochondrial surface. Rab7a is also recruited to damaged mitochondria, likely by its GEF Mon1-Ccz1. Rab7a’s activity at the mitochondria is dependent on proper cycling of its guanine nucleotide binding effected by its GEF and GAPs, like TBC1D15/17 and TBC1D5 (not shown here for brevity), and is also modulated by TBK1 phosphorylation. Rab7a at the damaged mitochondria facilitates the input of Atg9a containing membranes into the growing phagophore. See text for more details.