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. 2019 Mar 6;11(3):313. doi: 10.3390/cancers11030313

Figure 1.

Figure 1

Human Ewing sarcoma localizes to skeletal compartments where posterior HOX genes are expressed. (A) Human skeleton demonstrating anterior (yellow) and posterior (blue) expression of HOX genes on the left contrasted with frequency of Ewing sarcoma primary site (red) on the right. (B) Anatomic terms for skeletal regions of the limbs. (C) Cartoon demonstrating the location of the embryonic superficial zone (eSZ) on the ends of the bones that undergo endochondral ossification. The eSZ lies above the growth plate: resting zone (R), proliferative zone (P), hypertrophic zone (H). (D) Micrographs of E18.5 zeugopod, Hoxa11-EGFP (green fluorescent protein) in green, Pthrp-Lacz in blue in an adjacent section. Scale bars represent 100 µm. (E) Micrographs of E18.5 zeugopod, Hoxa11-GFP in green, anti-βgal in red. Scale bars represent 100 µm.