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. 2019 Mar 7;5(1):22. doi: 10.3390/ncrna5010022

Figure 1.

Figure 1

Identification of miR-21-5p, miR-23a-3p and miR-222-3p to detect left ventricular remodeling (LVR) after myocardial infarction (MI) and to predict heart failure (HF). (A) Design and (B) experimental selection and validation of the 13 candidate miRNAs predicted from the proteomic data obtained in LV of post-MI rats by the Ingenuity Pathway knowledge platform. Quantification of candidate miRNAs in LV and in plasma of post-MI rats at 7 days (Timepoint 0) and at 2 months and in plasma of REVE-2 patients at baseline (Timepoint 0), 3 month and 12 months after MI was published elsewhere [10]. ↑ and ↓ respectively indicate a significant increase and decrease of miRNAs (p < 0.05) detected between sham- and post-MI rats/between patients with no and high LVR, ↔ indicates no modulation, X indicates a lack of detection. MiRNAs remaining after the validation process are in bold.