Figure 9.

Temozolomide (TMZ) concentrations in U373 and Hs683 cell lysates after two hours of treatment with TMZ (200 µM). Cells were pre-treated with honokiol for 22 h (HONO + TMZ), vacquinol-1 for 15 h (VAC + TMZ) or MOMIPP for 3 h (MOMIPP + TMZ). Data are expressed as fold-change TMZ concentrations compared to its own control (TMZ alone) by box plots: line, median fold change; boxes, percentiles 25–75; whiskers, non-outlier ranges of 12 replicates. TMZ concentration of the cells treated with TMZ alone was normalized to 1. Statistical comparison has been made by the Mann–Whitney test. p < 0.05 (*), p < 0.01 (**) and p < 0.001 (***).