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. 2019 Feb 26;9(3):81. doi: 10.3390/biom9030081

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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NuMA binding does not reduce the local frustrated interactions in 4.1G-CTD. Frustrations of pair interactions in the top three clusters of 4.1G/NuMA complex are evaluated. The green lines indicate minimally frustrated interactions, while the red lines indicate highly frustrated interactions. Representations in the left column are free form 4.1G-CTD and the ones in the right column are 4.1G/NuMA complex. NuMA peptide is colored orange and 4.1G is colored according to its secondary structure.