Skip to main content
. 2019 Jan 21;5(1):11. doi: 10.3390/ncrna5010011

Figure 1.

Figure 1

Schematic diagram showing GAL10 sense and antisense transcriptions in galactose and dextrose-containing growth media, respectively. Bottom panel: The activator, Gal4, targets the co-activator, SAGA, to the GAL10 upstream activating sequence to enhance the formation of PIC, via the Mediator complex, independent of the TAFs that initiate GAL10 sense transcription a in galactose-containing growth medium [88,89]. The 19S proteasome subcomplex, or 19S RP, enhances the targeting of SAGA to Gal4 independent of the proteolytic activity of the 26S proteasome [97]. Top panel: Reb1 targets NuA4 KAT to the 3′-end of the GAL10 coding sequence (GAL10 3′ORF) for histone H4 acetylation and targeting of RNA polymerase II, via TFIID, to initiate GAL10 antisense transcription in dextrose-containing growth medium [83,84]. PIC—pre-initiation complex; SAGA—Spt-Ada-Gcn5-Acetyltransferase; TBP—TATA-box binding proteins; TAFs—TBP-associated factors; NuA4—Nucleosome acetyltransferase of histone H4; TFIID—Transcription factor IID, a complex of TBPs and a set of TAFs; TFIIB—Transcription factor IIB; and 19S RP—19S regulatory particle.