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. 2019 Mar 18;8(3):256. doi: 10.3390/cells8030256

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of T₂ administration on sWAT morphology. (a) Histological analysis, (b) morphometrical analysis, and (c) UCP1 immunohistochemistry of anterior sWAT of N, HFD, and HFD+T₂ rats. Adipocytes from HFD rats are significantly larger than those from N rats. After T₂ administration, the mean area and frequency distribution of the adipocytes were normalized to control values. A number of UCP1-stained paucilocular adipocytes are shown (arrows and panel (c)). More than 720 adipocytes were quantified from N = 3 rats from each group. Data are presented as Means ± SEM. ** p < 0.01 vs. N; *** p < 0.001 vs. HFD.