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. 2019 Mar 19;11(3):388. doi: 10.3390/cancers11030388

Figure 1.

Figure 1

NAB2 expression in head and neck squamous cell carcinoma (HNSCC) patient tissues. NAB2 protein expression was compared in normal epithelial cells (A) and primary tumors (B,C), and normal lymph nodes (Scale bar in C: 100 μM) (E) and paired metastatic lymph nodes (F,G) by immunohistochemistry. (C) and (G) are two-fold magnifications of the black rectangle images in (B) and (F), respectively. (Scale bar in G: 100 μM) Nuclei were counterstained with hematoxylin. Red arrows indicate some representative NAB2-expressing interstitial cancer-associated fibroblasts (CAFs) of primary and metastatic lymph node tissues. Black arrows indicate NAB2-negative cancer cells. NAB2-positive tumor cells and CAFs were counted in primary tumor tissues (D) and metastatic lymph node tissues (H). The boxes show the upper 75% and lower 25% quartiles of the measurements with respect to the median value (horizontal line in each box). Each dot represents an individual patient’s data, while a small open rectangle represents the mean value. Each bar represents the standard deviation.