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. 2019 Mar 19;11(3):388. doi: 10.3390/cancers11030388

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of NAB2 on CAF marker and MMP expression in patient fibroblasts. (A) NAB2 mRNA and protein expression in CAFs and paired NTFs from tissue specimens of three HNSCC patients was analyzed by qPCR and Western blotting, respectively. (B) NAB2 mRNA level is compared in cultured CAFs and paired HNSCC tissues. (C) CAFs and NTFs form P3 were transfected with NAB2 overexpression (NAB2-over) or control vector for 48 h. (D,E) mRNA and protein levels of CAF markers were analyzed in NTFs transfected with NAB2-over or control vector. (F) mRNA and protein levels of MMPs were analyzed under the same conditions. (G) CAFs were transfected with control siRNA or siNAB2 mixture for 48 h, and mRNA and protein levels of NAB2, CAF markers, and MMPs were analyzed. Results represent the mean ± standard deviation of two or three experiments.