Table 2.

miRNA co-regulated with their host genes and the mechanism described in MM.

Gene Locus	miRNA	Host Gene	Regulation Mechanism	Ref.
7q32.2	miR-335	MEST	Not by CNA	[33,72]
14q32.2	miR-342-3p	EVL	By promoter DNA methylation of its host gene, not by CNA	[33,72]
2q32.1-q32.2	miR-561	GULP1	Not by CNA	[33,72]
17q21.32	miR-152	COPZ2	Unknown	[33]
3q27.3-q28	miR-28-5p	LPP	By promoter DNA methylation of the host gene	[65]
17q23.1	miR-21	TMEM49	By an upstream enhancer, overlapping with intronic region of the host gene	[73]
21q21.3	miR-155	BIC	By promoter DNA methylation of the host gene	[68]