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. 2019 Apr 10;13:346. doi: 10.3389/fnins.2019.00346

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Copyright © 2019 Ouyang, Chen, Hou, Wang, Wang, Zou, Song, Huang, Guo and Weng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC2 expression was enhanced in a time-dependent manner in the lumbar spinal cord of CCI rats. (A) Immunofluorescent signal of HDAC2 (red) detected in the whole lumbar spinal cord section and the ipsilateral dorsal horn of rats. D3: 3 days after CCI; D7: 7 days after CCI; D14: 14 days after CCI; D21: 21 days after CCI; scale bar = 100 μm. (B) Western blot analysis showed that HDAC2 protein levels were altered in a time-dependent manner. A significant increase was detected on days 7 and 14 after CCI; n = 4 per group, ^∗p < 0.05, ^∗∗p < 0.01, compared to the Sham group.