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. 2019 Mar 16;9(1):42. doi: 10.3390/bios9010042

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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BRET-QD with coel-h pretreatment on Aβ-induced superoxide anions production. (A) Aβ treatment increased the fluorescent intensity of DHE by 40% as compared to control. The pretreatment of BRET-QD (66.7 pM) and coel-h (2.5 μM) suppressed the Aβ-induced increase in superoxide anion production back to that of control. Both the BRET-QD and Coel-h alone pretreatment lowered Aβ-induced superoxide anion, but not with a statistical significance. (B) Fluorescence images representing each experimental group. Each experiment was repeated three timesas compared to 5 μM Aβ. Data of each treatment group were normalized by the control for each independent experiment prior to statistical analysis. Reprinted from [92], with permission from Elsevier.