Figure 12.

NGR1 attenuated apoptosis via activating PINK1. rMC cells were transiently transfected with PINK1 siRNA. (A) The expression of VEGF and PEDF; (B) the apoptosis rate and JC-1 ratio; (C) the caspase-3 activity and cell viability. The results are expressed as the means ± SD (n = 10). Two groups were analysed by unpaired two-tailed Student’s t tests, and multiple groups were analysed by one-way analysis of variance (ANOVA); ## indicates a significant difference from HG-treated cells transfected with control siRNA (p < 0.01). ** indicates a significant difference from cells in the NGR1+HG group. (+), treatment with HG or NGR1; (−), treatment without HG or NGR1.