Table 1.

Summary of the studies discussed in the text.

LV Main Applications in GBM Research	References
Basic Studies
Dissecting the tumor biology	[10,11,12,13,14,18,19,23,26,27,28,29,30,31]
Identification of novel therapeutic targets	[15,16,17,20,21,22,24,25]
LV as Tools for Gene and Cell Therapy of GBM
Gene Therapy
Gene therapy approaches based on transgene expression	[37,38,39,55,56]
Gene therapy approaches based on silencing/gene editing	[46,47,50,51,53,54]
Gene Therapy approaches aimed at overcoming GMB resistance to therapy	[57,58,59,60,61,62,63,64,68]
Immunotherapy of GBM via LV expressing CARs	[72,73,74,75,76]
Cell Therapy
LV transduced cells as carriers of therapeutic molecules	[82,83,84,85,86,87,88,90,91]
LV to Create Animal Models
Murine models	[97,98,99,100,101,102,103,104]
Non-murine models	[93,94,95,96,105]

LV: Last-generation lentiviruses; GBM: Glioblastoma; CAR: chimeric antigen receptors.