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. 2019 Mar 16;11(3):376. doi: 10.3390/cancers11030376

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Chemoresistance pathways involving K⁺ channels. K⁺ channels could modulate the sensitivity to different chemotherapies by regulating pro-survival pathways (intrinsec or extrinsec apoptosis pathways, volume regulation, Akt/RAS/MAPK pathways, interacting with receptors or transporters). MDR: Multidrug Resistance Protein; EGFR: Epidermal Growth Factor Receptor; CXCR4: C-X-C Chemokine Receptor type 4; TRAILR: TRAIL Receptor; Cyt C: Cytochrome C; AIF: Apoptosis Inducing Factor; SMAC: Second Mitochondria-derived Activator of Caspases; RVD: Regulatory Volume Decrease.