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Immunohistochemical analysis of SOX2 (Sex-determining region Y-box 2) expression in laryngeal precancerous lesions. Normal adjacent epithelia showed negative staining (A). Representative examples of laryngeal dysplasias showing negative (B), and positive nuclear SOX2 staining (C,D), compared to the negative expression in normal-adjacent epithelia (right side). (E) Higher magnification from D. (F) H&E staining from D.
