Table 1.

Expression of VEGFR3 in tumor cells.

Tumor Type	Detection	Expression	Correlate to Lymph Angiogenesis	Correlate to Lymph Node Metastasis	Ref.
Urothelial cancer	IHC	Tumor cells	−	−	[53]
Breast cancer	IHC, RT-PCR, Western blot	Tumor cells	−	+	[54,55,56]
Lung cancer	IHC, qRT-PCR, Western blot	Tumor cells	−	+	[57,58]
Ovarian cancer	qRT-PCR, IHC, Western blot	Tumor cells	+	+	[59,60]
Renal cell cancer	IHC	Tumor cells	−	+	[61,62,63]
Endometrial cancer	IHC, qRT-PCR, Western blot	Tumor cells	−	+	[64,65]
Colorectal cancer	IHC, qRT-PCR, Western blot	Tumor cells	+	+	[66,67,68]
Gastric cancer	IHC, qRT-PCR	Tumor cells	+	+	[69,70]
Bladder cancer	Western blot	Tumor cells	−	−	[71]
Oral cancer	IHC	Tumor cells	+	+	[72]
Head and neck cancer	qRT-PCR, qMSP-PCR	Tumor cells	−	−	[73]
Esophageal cancer	IHC	Tumor cells	−	−	[74,75]
Cervical cancer	IHC, in situ hybridization, qRT-PCR, Western blot	Tumor cells	+	+	[76,77]
Prostate cancer	IHC, in situ hybridization, qRT-PCR	Tumor cells	+	+	[78,79]
Thyroid cancer	IHC	Tumor cells	−	−	[80,81]
Pancreatic cancer	Western blot	Tumor cells	+	+	[82,83]
Neuroblastoma	RT-PCR, Western blot	Tumor cells	−	−	[84,85]
Melanoma	Western blot, IHC	Tumor cells	+	−	[86,87]
Glioblastoma	In situ hybridization, qRT-PCR	Tumor cells	−	−	[88,89]
Osteosarcoma	IHC	Tumor cells	−	−	[90]
Laryngeal cancer	RT-PCR	Tumor cells	+	−	[91]
Basal cell carcinoma	qRT-PCR, Western blot	Tumor cells	−	+	[92]
Acute myeloid leukemia	RT-PCR, IHC	Acute myeloid leukemia (AML) natural killer (NK) cells	−	−	[93]

+, the expression of VEGFR3 is correlated with angiogenesis or lymph node metastasis; −, the expression of VEGFR3 is not correlated with angiogenesis or lymph node metastasis.