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. 2019 Feb 27;11(3):281. doi: 10.3390/cancers11030281

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Characterization of Lipo-IRI (irinotecan) formulation. The size of Lipo-IRI was estimated using (A) dynamic light scattering (DLS) and (B) nanoparticle tracking analysis (NTA). The size distribution and particle concentration were calculated as intensity and particles/ml, respectively. The cryo-transmission electron microscopy (TEM) imaging was performed on a drug-loaded 1,2-Distearoyl-sn-glycero-phosphocholine (DSPC)/Cholesterol formulation either (C) with or (D) without irinotecan (IRI). (10 μmol/mL phospholipid; scale bar represents 100 nm).