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. 2019 Feb 27;11(3):281. doi: 10.3390/cancers11030281

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Enhanced effect of targeted liposome-encapsulated treatment combination in an hCRC large tumor model. The drug internalization (A) and cytotoxicity (B) of pHCT74-Lipo-IRI were compared with non-targeted Lipo-IRI in vitro. The tumor bearing mice (500 mm³) received PBS, IRI + Dox, Lipo-Dox + Lipo-IRI, pHCT74-Lipo-IRI + pHCT74-Lipo-Dox 10 times over the course of 5 weeks (twice weekly × 5). The tumor volume and body weight are shown (C and D). A Kaplan-Meier curve and median survival of each group are shown (E). The data were analyzed by GraphPad Prism 6.0 software (n = 7). * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001.