Scheme 3.
Synthesis of 1st generation dendrimers with terminal lysine (Lys) (12–15, and Nε-deprotected compounds 16–19): (i) Boc-Lys(Z)-OH, DCC/HOBt, Et3N, DMF, 48 - 72 h; (ii) H2/10% Pd-C, MeOH.
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