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Effect of STIM1 depletion on ERK1/2 phosphorylation induced by CDDP. (A) Immunoblot analysis showing the effect of 24 h treatment with 25 µM CDDP on pERK1/2 in siCTRL or siSTIM1 transfected cells. (B) Immunoblot analysis showing the effect of 50 µM PD98059 of PARP-1 cleavage and p53 accumulation induced by 24 h treatment with 25 µM CDDP. Lanes separated by a thin line have been cropped from the same immunoblot.
