Skip to main content
. 2019 Mar 1;8(3):209. doi: 10.3390/cells8030209

Figure 1.

Figure 1

A schematic of the γ-secretase complex. Presenilins represent the catalytic components of γ-secretase complexes that contain three additional proteins presenilin-enhancer-2 (PEN2), nicastrin, and anterior-pharynx defective-1 (APH1). The aspartyl residues in transmembrane domains 6 and 7 required for catalytic activity are indicated by orange circles.