Table 2.

Relationship between health-related quality of life indicators, clinical evaluation of patient’s functioning, and miR-34 expression in glioblastoma patients. Spearman rho.

Scales and Domains	miR-34 Expression
	Total Sample		Females		Males
	rho	Sig.	rho	Sig.	rho	Sig.
	Health-related Quality of life
EORTC QLQ-C30 A
Global evaluation of health	−0.05	0.76	−0.11	0.62	0.05	0.86
Physical functioning	0.30	0.06	0.18	0.40	0.66	0.01
Role functioning	0.05	0.78	−0.13	0.56	0.27	0.32
Emotional functioning	0.14	0.39	0.15	0.49	0.27	0.32
Cognitive functioning	0.11	0.52	−0.09	0.68	0.44	0.09
Social functioning	0.26	0.12	0.09	0.67	0.44	0.09
QLQ C30 Total Score	0.31	0.06	0.26	0.25	0.24	0.36
EORTC QLQ-BN20 B
Future uncertainty	−0.11	0.50	−0.14	0.52	−0.07	0.81
Visual difficulties	0.06	0.74	0.25	0.25	−0.22	0.43
Communication	0.15	0.38	0.18	0.42	−0.14	0.62
Motor difficulties	0.13	0.42	0.23	0.30	−0.17	0.52
Headaches	−0.08	0.64	0.07	0.70	−0.19	0.49
Seizures	0.15	0.36	−0.16	0.46	0.42	0.12
Drowsiness	−0.34	0.03	−0.20	0.37	−0.49	0.05
Hair loss	−0.01	0.97	0.33	0.13	−0.42	0.11
Itchy skin	−0.06	0.71	0.13	0.54	−0.27	0.32
Leg weakness	−0.26	0.11	−0.17	0.45	−0.42	−0.11
Bladder control	0.19	0.24	0.37	0.08	−0.01	0.98
	Depression
PHQ-9 C	−0.36	0.03	−0.36	0.09	−0.37	0.16
	Level of functioning
KPS at time of admission D	0.36	0.03	0.19	0.41	0.34	0.22
GOS at time of discharge E	0.17	0.30	0.11	0.62	0.09	0.74

^A The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire QLQ-30. Higher scores represent better functioning; ^B The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Brain tumor module QLQ-BN20. Higher scores represent higher symptom burden. ^C Patient Health Questionnaire-9. Higher scores indicate higher levels of depression. ^D Karnofsky Performance Scale. Higher scores represent better functioning.^E Glasgow Outcome Scale. Bolded values indicate significant associations. Higher scores represent better functional outcomes after surgical treatment.