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. 2019 Mar 20;8(3):262. doi: 10.3390/cells8030262

Figure 4.

Figure 4

Effect of proteasomes on chemotaxis during RRMS relapse and remission. All simulations are done for standard proteasomes only (left column), immunoproteasomes only (middle column), and 50% standard- and immuno-proteasomes (right column). (A) Simulation of OPN-FL and extracellular proteasome concentrations over time in MS patient serum. The behavior of OPN-FL concentration during relapse is given, and the behavior of extracellular proteasome concentration is a result of the modeled system. Here, we assume that only OPN-FL is present in the extracellular space. (B) Simulation of the time course of proteasome-generated OPN fragments in MS patient serum. (C) Level of chemotaxis over the course of the disease in MS patients. The chemotaxis is computed based on the cell migration experiments performed with HUVECs (Figure 3). Additionally, to the overall expected chemotaxis levels, the chemotaxis based only on OPN-FL, only on standard proteasomes, and only on immunoproteasomes is shown, respectively.