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. 2019 Mar 20;8(3):262. doi: 10.3390/cells8030262

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Extracellular OPN and proteasome dynamics and related chemotaxis for HUVECs, lymphocytes, and monocytes. (A) Chemotactic indices of OPNs (OPN-FL, OPN-N, and OPN-C) as well as their derived fragments generated by standard proteasomes for HUVECs, lymphocytes, and monocytes. (B) Chemotaxis levels over the course of the disease for MS patients based on cell migration experiments [25] performed with HUVECs (left), lymphocytes (middle), or monocytes (right). Simulations are based assuming that only standard proteasomes (absence of immunoproteasome) and only OPN-FL (absence of thrombin) are present in the system.