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. 2019 Mar 6;11(3):320. doi: 10.3390/cancers11030320

Figure 1.

Figure 1

Connexin mRNA gene expression in normal tissue (blue) and in LUAD and LUSC tumours (red). (a) Expression of GJB2 (encoding Cx26). Significant upregulation is seen in both tumour subtypes, particularly LUSC. (b) Expression of GJB4 (encoding Cx30.3) is mainly upregulated in LUSC. (c) Expression of GJB2 (encoding Cx32) is specifically downregulated in LUSC. (d) Expression of GJA1 (encoding Cx43) is high in normal tissue but shows only a slight upregulation in LUAD and a slight downregulation in LUSC. The figure also highlights the occurrence of some outliers in tumours, such as very low expression of Cx26 and Cx30.3 in some LUSCs despite a general upregulation and very high expression of Cx32 in some LUSCs despite a general downregulation.