PCa	Prostate cancer
BPH	Benign prstate hyperplasia
DRE	Digital rectal exam
GS	Gleason score
HC	Healthy controls
NEM	No evidence of malignancy
PSA	Prostate specific antigen
TNM	Tumour-lymphnode-metastasis classification
SP	Seminal plasma
EV	Extracellular vesicles
ADT	Androgen deprivation therapy
AJCC	American Joint Committee on Cancer
CRPC	Castration-resistant prostate cancer
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
MS	Mass spectrometry
GC-MS	Gas chromatography mass spectrometry
MRIS	Magnetic resonance imaging spectroscopy
NMR	Nuclear magnetic resonance
LC-MS	Liquid chromatography mass spectrometry
LC-QTOF-MS	Liquid chromatography quadrupole time-of-flight mass spectrometry
GC-TOF-MS	Gas chromatography time-of-flight mass spectrometry
HPLC-ESI+QTOF-sMS	High performance liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry
UHPLC-MS	Ultra high performance liquid chromatography mass spectrometry
HR-MAS-1H-MRS	High resolution magic angle spinning proton magnetic resonance spectroscopy
LC-ESI-MS	Liquid chromatography electrospray ionization mass spectrometry
PCA	Principal component analysis
PLS-DA	Partial least squares-discriminant analysis
RF	Random forest
OSC-PLS	Orthogonal signal correction for partial least square analysis
OPLS-DA	Orthogonal projections to latent structures-discriminant analysis
ROC	Receiver operator characteristics
SVM	Support vector machine
VIP	Variable importance of projection
LDA	Linear discrimination analysis
DFA	Discriminant function analysis
ANOVA	One-way analysis of variance
AUC	Area under the curve
DRW-GM	Directed random walk on gene metabolite pathway graph
(CCP/C)	Choline+creatine+polyamines over citrate
Cho	Choline
Cit	Citrate
Cr	Creatinine
GPC	Glycerophosphocholine
GPE	Glycerophospho-ethanolamine
LCFA	Long chain fatty acid
mI	Myo-inositol
NAD	Nicotinamide adenine dinucleotide (NAD+)
PC	Phosphocholine
PE	Phosphoethanolamine
Spm	Spermine
TMAO	Trimethylamine N-oxide