Figure 6.

Diabetes-induced aberrant mitochondria remodeling was prevented by empagliflozin. Note that in all panels (A–F) the mitochondria are of smaller size and that the mitochondria matrix is electron dense (pseudo-colored green encircled with white lines) in contrast to the swollen aMt with loss of mitochondrial matrix electron density and loss of crista in the previous Figure 5. Magnification 6000× (panel (A)); 2000× (panel (B)), and 4000× (panels (C–F)); Scale bars = 0.5 μm in all images except for panel (B) which has a scale bar = 1 μm. AC = astrocyte; EC = endothelial cell; M = myelin; OL= oligodendrocyte; PcP = pericyte foot process; UnM = unmyelinated.