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. 2019 Mar 26;8(3):285. doi: 10.3390/cells8030285

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IL-6-, IL-12-, and IL-23-induced STAT activation in resting T, B, and NK cells. (A) Dot plot example of IL-6-induced STAT3-pY in resting lymphocytes; isotype control is shown in the upper panel. (B–D) Frequency of IL-6-induced STAT3-pY+ CD4+ T cells (B), CD8+ T cells (C), and B cells (D) in healthy controls (HC) and patients with RRMS. (E) Dot plot example of IL-12-induced STAT4-pY in resting lymphocytes; isotype control is shown in the upper panel. (F–H) Frequency of IL-12-induced STAT4-pY+ CD4+ T cells (F), CD8+ T cells (G), and NK cells (H) in healthy controls and patients with RRMS. (I) Dot plot example of IL-23-induced STAT3-pY+ in resting lymphocytes; isotype control is shown in the upper panel. (J–L) Frequency of IL-23-induced STAT3-pY+ CD4+ T cells (J), CD8+ T cells (K), and NK cells (L) in healthy controls and patients with RRMS. The median value is shown for all groups analyzed.