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. 2019 Mar 26;8(3):285. doi: 10.3390/cells8030285

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IL-6, IL-12, and IL-23 STAT-pathway weighted genetic risk score (wGRS) and responsiveness of primed T cells. (A–C) Correlation between IL-12-induced STAT4-pY and IL-23-induced STAT3-pY (A), between IL-12-induced STAT4-pY and IL-6-induced STAT3-pY (B), and between IL-23-induced STAT3-pY and IL-6-induced STAT3-pY (C) in primed CD4+ T cells. (D–F) Correlation between IL-12-induced STAT4-pY and IL-23-induced STAT3-pY (D), between IL-12-induced STAT4-pY and IL-6-induced STAT3-pY (E), and between IL-23-induced STAT3-pY and IL-6-induced STAT3-pY (F) in primed CD8+ T cells. (G–I) Correlation between the IL-6 pathway wGRS and IL-6-induced STAT3-pY (G), the IL-12 pathway wGRS and IL-12-induced STAT4-pY (H), and the IL-23 pathway wGRS and IL-23-induced STAT3-pY (I) in primed CD4+ T cells. (J–L) Correlation between the IL-6 pathway wGRS and IL-6-induced STAT3-pY (J), the IL-12 pathway wGRS and IL-12-induced STAT4-pY (K), and the IL-23 pathway wGRS and IL-23-induced STAT3-pY (L) in primed CD8+ T cells. The p-value and Spearman’s correlation coefficient r_s is shown for all plots.