FIG. 3.
Comparison of relative plasma miRNA abundance in severe TBI versus orthopedic injury patients. Purified plasma RNA was assayed for (A) miR-16, (B) miR-92a, or (C) miR-765 relative abundance by TaqMan qRT-PCR assay. Dot histogram plots of the ΔCT values are shown using the mean orthopedic CT as the reference. (D) Area under the curve (AUC) values obtained from ROC analysis for each miRNA, indicating the diagnostic potential of each miRNA target (*p < 0.05 by two-tailed Student's t-test; orthopedic injury [Ortho], n = 8; severe TBI [sTBI], n = 7; miRNA, microRNA; qRT-PCR, quantitative reverse transcriptase polymerase chain reaction; TBI, traumatic brain injury; ROC, receiver operating characteristic).