FIG. 4.
Diagnostic value of plasma miRNAs for identifying mild TBI patients. RNA was purified from plasma samples collected within the first 10 h after injury, and miRNA relative abundance was determined by qRT-PCR. Dot histogram plots of the ΔCT values for (A) miR-16, (B) miR-26a, (C) miR-92a, (D) miR-638, or (E) miR-765. (F) Area under the curve (AUC) values obtained from ROC analysis for each miRNA (*p < 0.05 by two-tailed Student's t-test; healthy volunteer [HV], n = 8; mild TBI [mTBI], n = 11; miRNA, microRNA; qRT-PCR, quantitative reverse transcriptase polymerase chain reaction; TBI, traumatic brain injury; ROC, receiver operating characteristic).