Skip to main content
. 2011 Aug 1;22(8):935–949. doi: 10.1089/hum.2010.121

FIG. 6.

FIG. 6.

Serum enzyme activity on day 9, 30, and 45 following rAAV9-hADA or lactated Ringer's PBS administration to ADA-SCID KO mice. (A) hADA activity in mouse serum on day 9. At this time point, the average level of enzyme activity is 2–3 units higher in treated versus untreated KO mice. (B) hADA activity on day 30. At this time point, the average level of ADA activity decreases in the treated mice, although enzyme activity remains relatively stable in the untreated mice. (C) Observed serum enzyme activity on day 45. On day 45, although the average level of ADA activity continues to remain stable at approximately 4 units for untreated mice, average enzyme activity increases to nearly 8 units in treated mice. Overall, this time-course study suggests a trend of increasing and decreasing levels of serum ADA activity in treated versus untreated KO mice, which may parallel cycles of enzyme synthesis and degradation in the treated mice. However, given the large SDs, the observed trend is not statistically significant. Post-IV, post-intravenous.