FIG. 7.

Lymphocyte populations followed over a 90-day time course following intramuscular injections of rAAV1-hADA or lactated Ringer's PBS in ADA-SCID KO mice. (Left panel) Total lymphocyte and lymphocyte subset populations at monthly time points post-injection (pI) of rAAV1-hADA into KO mice. (Right panel) Equivalent lymphocyte populations for untreated KO mice administered PBS (negative control [NC]). Overall, a comparison of lymphocyte populations in the treated versus the untreated KO mice reveals no positive trend toward lymphocyte proliferation in the treated group.