Skip to main content
. Author manuscript; available in PMC: 2019 Apr 17.
Published in final edited form as: Sci Transl Med. 2018 Sep 26;10(460):eaap9489. doi: 10.1126/scitranslmed.aap9489

Fig. 2. Timeline for a study patient undergoing allo-HSCT and randomized to receive auto-FMT.

Fig. 2.

(A) Allo-HSCT for study patient T5 was initiated with pretransplant conditioning [chemotherapy and total body irradiation (TBI)], followed by allogeneic hematopoietic stem cell infusion (day 0). Various antibiotics were given throughout this period for prophylactic and treatment purposes. (B) Neutrophil count reached a nadir but later recovered after hematopoietic stem cell engraftment. (C) The subject’s intestinal microbiota composition was altered as shown by sequencing of longitudinally collected fecal samples obtained before allo-HSCT and up to day 91 after transplant. After stem cell engraftment, randomization assigned patient T5 to the treatment arm and the patient received an auto-FMT on day 49 using the patient’s initial pretreatment feces, which had been collected and stored before allo-HSCT (initial feces collected at day −21). The intestinal microbiota was restored to that before transplant in terms of (D) its diversity (α-diversity quantified by the IS index) and (E) its percent similarity to the initial fecal microbiota.